PROGRAMME
28th SEPTEMBER 2022
16:00 - 16:30
Keynote Lecture
Supported by an unrestricted grant of Sanofi
Chairs: Gianmarco Podda (Italy), Ilaria Canobbio (Italy)
Pathophysiology of platelet adhesion and inhibition of platelet - von Willebrand factor interaction
Raimondo De Cristofaro (Italy)16:45 - 17:00
Welcome
Ilaria Canobbio (Italy), Marco Cattaneo (Italy), Gianmarco Podda (Italy), Mauro Torti (Italy)
Inaugural Session
Chairs: Marco Cattaneo (Italy), Mauro Torti (Italy)
17:00 - 17:30
Platelets, thromboinflammation and COVID-19
Meinrad Gawaz (Germany)
17:30 - 18:00
Discussion
29th SEPTEMBER 2022
Session 1
Chairs: Benedetta Izzi (Spain), Rossella Marcucci (Italy)
09:00 - 09:30
Keynote Lecture
P2Y12 antagonists monotherapy in patients with acute coronary syndrome?
Felice Gragnano (Italy)
Oral Communications
09:30 - 09:45
Identification of novel inhibitors of the platelet collagen receptor GPVI by a phenotypic screening
Sara Troitiño Cora (Spain)
09:45 - 10:00
Structural studies of glycoprotein VI: from extracellular domains to full-length
Alexandre Slater (UK)
10:00 - 10:15
Ultra-high throughput screening identifies novel calcium-dependent antiplatelet drugs with discriminative mode of receptor-dependent action
Delia Irene Fernández De La Fuente (The Netherlands)
10:15 - 10:30
GPVI drives pulmonary inflammation by mediating local platelet-neutrophil complex formation and neutrophil activation in a murine model of acute respiratory distress syndrome
Philipp Burkard (Germany)
10:30 - 11:00
Coffee break
Session 2
Chairs: Alessandro Malara (Italy), Raimondo De Cristofaro (Italy)
11:00 - 11:30
Keynote Lecture
Platelet generation from circulating megakaryocytes
Alastair Poole (UK)
Oral Communications
11:30 - 11:45
Light-induced ion influx triggers megakaryocyte polarization
Yujing Zhang (Germany)
11:45 - 12:00
Pharmacological inhibition of SHP2 inhibits megakaryopoiesis, thrombopoiesis and MPL signalling
Alexandra Mazharian (France)
12:00 - 12:15
PIM kinase: a novel regulator of megakaryocyte and platelet production and function
Amanda Unsworth (UK)
12:15 - 12:30
Reduced platelet glycoprotein Ibα shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
Paola Giustina Maria Simeone (Italy)
12:30 - 14:00
Poster Viewing Session / Lunch
Session 3
Chairs: Sarah Jones (UK), Pasquale Pignatelli (Italy)
14:00 - 14:30
Keynote Lecture
Phosphoinositides in the regulation of platelet generation and function
Bernard Payrastre (France)
Oral Communications
14:30 - 14:45
The C-type lectin CD93 regulates platelet activation induced by PAR4 stimulation
Silvia Trivigno (Italy)
14:45 - 15:00
Conformational change in platelet αIIbβ3 induce PKC-dependent serine 284 phosphorylation of junctional adhesion molecule-A and Rap1 activation
Meghna Naik (US)
15:00 - 15:15
Haemorrhagic complications in cholera – a possible role of Vibrio cholerae outer membrane vesicles via impairment of platelet function
Anita Pirabe (Austria)
15:15 - 15:30
Ticagrelor prevents infective endocarditis by mitigating Staphylococcus aureus virulence
Nicolas Jacques (Belgium)
15:30 - 16:00
Coffee break
Session 4
Chairs: Fabio Pulcinelli (Italy), Isabella Russo (Italy)
16:00 - 16:30
Keynote Lecture
Treatment of immune thrombocytopenia
Nichola Cooper (UK)
Oral Communications
16:30 - 16:45
Ultrastructural changes in platelets associated with viral xenophagy in severe COVID-19 patients
Cédric Garcia (France)
16:45 - 17.00
Single-cell RNA sequencing reveals aberrant megakaryocyte-erythroid progenitor and megakaryocyte populations in thrombocytopenic ETV6 variant carriers
Timothée Jr Bigot (France)
17:00 - 17:15
Integrin α5β1 in haemostasis and arterial thrombosis in mice
Pierre Mangin (France)
17:15 - 17:30
Temporal labelling uncovers functional and molecular changes of platelets as they age in the circulation
Paul Armstrong (UK)
20:30
Conference dinner
30th SEPTEMBER 2022
Session 5
Chairs: Francesca Santilli (Italy), Valeria Catani (Italy)
09:00 - 09:30
Keynote Lecture
Microfluidic devices to study platelet thrombus formation in vitro
Matthew Harper (UK)
Oral Communications
09:30 - 09:45
GPIbα shedding is restricted to the inner platelet membrane
Caitlin Debaene (Belgium)
09:45 - 10:00
SARS-CoV-2 infection is associated with activated but exhausted platelets
Mariangela Scavone (Italy)
10:00 - 10:15
TNF-alpha-induced endothelial dysregulation enhances platelet activation under shear and in stasis: a multi-omics approach
Claudia Schönichen (The Netherlands)
10:15 - 10:30
Platelet dysfunction in HFpEF patients: reduced platelet activation and thrombus formation under flow
Giorgia D'Italia (The Netherlands)
10:30 - 11:00
Coffee break
Session 6
Chairs: Pierre Fontana (Switzerland), Anna Savoia (Italy)
11:00 - 11:30
Keynote Lecture
Platelet function defects studied with Next Generation Sequencing: present and future perspectives
Eva Leinoe (Denmark)
Oral Communications
11:30 - 11:45
Platelet RNA sequencing for SLFN14 K219N deficiency shows overexpression of ribosomal genes
Fabienne Ver Donck (Belgium)
11:45 - 12:00
Molecular insights into the cause and treatment of congenital thrombocytopenia in mice lacking the co-inhibitory receptor G6b-B
Yotis Senis (France)
12:00 - 12:15
How to assess the ability of plasma exchange to reduce on COVID-associated thrombo-inflammation with an in vitro platelet-endothelium co-culture model
Theo Ebermeyer (France)
12:15 - 12:30
Blood platelets at the crossroad between Alzheimer's disease and ageing-related frailty
Mauro Vismara (Italy)
12:30 - 14:00
Poster Viewing Session / Lunch
Session 7
Chairs: Lucia Stefanini (Italy), Pietro Minuz (Italy)
14:00 - 14:30
Keynote Lecture
Platelets in atherosclerosis: from experimental models to clinical relevance
Judith Cosemans (The Netherlands)
Oral Communications
14:30 - 14:45
Platelet-released mitochondria interact with neutrophils causing alterations in their phenotype
Harriet Allan (UK)
14:45 - 15:00
Carotid stent thrombosis in acute stroke with tandem lesions: focus on the mechanism and its prevention
Axelle Kern (France)
15:00 - 15:15
Kinetics of circulating extracellular vesicles after low-dose aspirin administration in patients at cardiovascular risk
Maurizio Frezza (Italy)
15:15 - 15:30
Divalent ligands activate C-type lectin-like receptor 2 in mice but not in human platelets
Joanne Clark (UK)
15:30
Closing remarks
Ilaria Canobbio (Italy), Marco Cattaneo (Italy), Gianmarco Podda (Italy), Mauro Torti (Italy)