Keynote Lecture

Supported by an unrestricted grant of Sanofi
Chairs: Gianmarco Podda (Italy), Ilaria Canobbio (Italy)

Pathophysiology of platelet adhesion and inhibition of platelet - von Willebrand factor interaction

Welcome

Ilaria Canobbio (Italy), Marco Cattaneo (Italy), Gianmarco Podda (Italy), Mauro Torti (Italy)

Inaugural Session

Chairs: Marco Cattaneo (Italy), Mauro Torti (Italy)

Platelets, thromboinflammation and COVID-19

Meinrad Gawaz (Germany)

Discussion

Session 1

Chairs: Benedetta Izzi (Spain), Rossella Marcucci (Italy)

Keynote Lecture

P2Y12 antagonists monotherapy in patients with acute coronary syndrome?

Felice Gragnano (Italy)

Identification of novel inhibitors of the platelet collagen receptor GPVI by a phenotypic screening

Sara Troitiño Cora (Spain)

Structural studies of glycoprotein VI: from extracellular domains to full-length

Alexandre Slater (UK)

Ultra-high throughput screening identifies novel calcium-dependent antiplatelet drugs with discriminative mode of receptor-dependent action

Delia Irene Fernández De La Fuente (The Netherlands)

GPVI drives pulmonary inflammation by mediating local platelet-neutrophil complex formation and neutrophil activation in a murine model of acute respiratory distress syndrome

Philipp Burkard (Germany)

Session 2

Chairs: Alessandro Malara (Italy), Raimondo De Cristofaro (Italy)

Keynote Lecture

Platelet generation from circulating megakaryocytes

Alastair Poole (UK)

Oral Communications

Light-induced ion influx triggers megakaryocyte polarization

Yujing Zhang (Germany)

Pharmacological inhibition of SHP2 inhibits megakaryopoiesis, thrombopoiesis and MPL signalling

Alexandra Mazharian (France)

PIM kinase: a novel regulator of megakaryocyte and platelet production and function

Amanda Unsworth (UK)

Reduced platelet glycoprotein Ibα shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen

Paola Giustina Maria Simeone (Italy)

Session 3

Chairs: Sarah Jones (UK), Pasquale Pignatelli (Italy)

Keynote Lecture

Phosphoinositides in the regulation of platelet generation and function

Bernard Payrastre (France)

Oral Communications

The C-type lectin CD93 regulates platelet activation induced by PAR4 stimulation

Silvia Trivigno (Italy)

Conformational change in platelet αIIbβ3 induce PKC-dependent serine 284 phosphorylation of junctional adhesion molecule-A and Rap1 activation

Meghna Naik (US)

Haemorrhagic complications in cholera – a possible role of Vibrio cholerae outer membrane vesicles via impairment of platelet function

Anita Pirabe (Austria)

Ticagrelor prevents infective endocarditis by mitigating Staphylococcus aureus virulence

Nicolas Jacques (Belgium)

Session 4

Chairs: Fabio Pulcinelli (Italy), Isabella Russo (Italy)

Keynote Lecture

Treatment of immune thrombocytopenia

Nichola Cooper (UK)

Oral Communications

Ultrastructural changes in platelets associated with viral xenophagy in severe COVID-19 patients

Cédric Garcia (France)

Single-cell RNA sequencing reveals aberrant megakaryocyte-erythroid progenitor and megakaryocyte populations in thrombocytopenic ETV6 variant carriers

Timothée Jr Bigot (France)

Integrin α5β1 in haemostasis and arterial thrombosis in mice

Pierre Mangin (France)

Temporal labelling uncovers functional and molecular changes of platelets as they age in the circulation

Paul Armstrong (UK)

Session 5

Chairs: Francesca Santilli (Italy), Valeria Catani (Italy)

Keynote Lecture

Microfluidic devices to study platelet thrombus formation in vitro

Matthew Harper (UK)

Oral Communications

GPIbα shedding is restricted to the inner platelet membrane

Caitlin Debaene (Belgium)

SARS-CoV-2 infection is associated with activated but exhausted platelets

Mariangela Scavone (Italy)

TNF-alpha-induced endothelial dysregulation enhances platelet activation under shear and in stasis: a multi-omics approach

Claudia Schönichen (The Netherlands)

Platelet dysfunction in HFpEF patients: reduced platelet activation and thrombus formation under flow

Giorgia D'Italia (The Netherlands)

Session 6

Chairs: Pierre Fontana (Switzerland), Anna Savoia (Italy)

Keynote Lecture

Platelet function defects studied with Next Generation Sequencing: present and future perspectives

Eva Leinoe (Denmark)

Oral Communications

Platelet RNA sequencing for SLFN14 K219N deficiency shows overexpression of ribosomal genes

Fabienne Ver Donck (Belgium)

Molecular insights into the cause and treatment of congenital thrombocytopenia in mice lacking the co-inhibitory receptor G6b-B

Yotis Senis (France)

How to assess the ability of plasma exchange to reduce on COVID-associated thrombo-inflammation with an in vitro platelet-endothelium co-culture model

Theo Ebermeyer (France)

Blood platelets at the crossroad between Alzheimer's disease and ageing-related frailty

Mauro Vismara (Italy)

Session 7

Chairs: Lucia Stefanini (Italy), Pietro Minuz (Italy)

Keynote Lecture

Platelets in atherosclerosis: from experimental models to clinical relevance

Judith Cosemans (The Netherlands)

Oral Communications

Platelet-released mitochondria interact with neutrophils causing alterations in their phenotype

Harriet Allan (UK)

Carotid stent thrombosis in acute stroke with tandem lesions: focus on the mechanism and its prevention

Axelle Kern (France)

Kinetics of circulating extracellular vesicles after low-dose aspirin administration in patients at cardiovascular risk

Maurizio Frezza (Italy)

Divalent ligands activate C-type lectin-like receptor 2 in mice but not in human platelets

Joanne Clark (UK)

Closing remarks

Ilaria Canobbio (Italy), Marco Cattaneo (Italy), Gianmarco Podda (Italy), Mauro Torti (Italy)